Two cases of tuberculosis with multiple drug hypersensitivity after drug-induced hypersensitivity syndrome

被引：7

作者：

Sekine, Akimasa ^{[1
]}

Saito, Takefumi ^{[1
]}

Ito, Shusaku ^{[2
]}

Tsunoda, Yoshiya ^{[1
]}

Sumazaki, Yuki ^{[1
]}

Tanaka, Toru ^{[1
]}

Takoi, Hiroyuki ^{[1
]}

Lin, Shih-Yuan ^{[1
]}

Yatagai, Yohei ^{[1
]}

Hayasihara, Kenji ^{[1
]}

机构：

[1] Ibaraki Higashi Natl Hosp, Natl Hosp Org, Dept Resp Med, Terunuma 825, Tokai, Ibaraki, Japan

[2] Hitachi Gen Hosp, Dept Dermatol, Hitachi, Ibaraki, Japan

来源：

RESPIRATORY INVESTIGATION | 2012年 / 50卷 / 02期

关键词：

Drug-induced hypersensitivity syndrome; Drug rash; Multiple drug hypersensitivity; Tuberculosis; Allergy;

D O I：

10.1016/j.resinv.2012.04.004

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Here, we report 2 cases of drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine and allopurinol during tuberculosis treatment. Both patients also developed multiple drug hypersensitivity (MDH) to several antituberculosis drugs that were used at around the period of DIHS onset, and thus, the treatment could not be successfully completed. Our cases show that MDH can easily occur after development of DIHS. Considering that treatment for tuberculosis requires long-term management with several drugs, it is important to refrain from administering drugs that can cause DIHS during tuberculosis treatment. (C) 2012 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.

引用

页码：70 / 75

页数：6

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