A GENE FROM THE REGION OF THE HUMAN X-INACTIVATION CENTER IS EXPRESSED EXCLUSIVELY FROM THE INACTIVE X-CHROMOSOME

被引：1290
作者：
BROWN, CJ
BALLABIO, A
RUPERT, JL
LAFRENIERE, RG
GROMPE, M
TONLORENZI, R
WILLARD, HF
机构：
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT GENET,STANFORD,CA 94305
[2] BAYLOR UNIV,INST MOLEC GENET,HOUSTON,TX 77030
来源：
NATURE | 1991年 / 349卷 / 6304期
关键词：
D O I：
10.1038/349038a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
X-chromosome inactivation results in the cis-limited dosage compensation of genes on one of the pair of X chromosomes in mammalian females. Although most X-linked genes are believed to be subject to inactivation, several are known to be expressed from both active and inactive X chromosomes. Here we describe an X-linked gene with a novel expression pattern-transcript are detected only from the inactive X chromosome (X(i)) and not from the active X chromosome (X(a)). This gene, called XIST (for X(i)-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation.
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页码：38 / 44
页数：7
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