ACUTE TOXICITY IN THE RAT FOLLOWING EITHER ORAL OR INHALATION EXPOSURE

被引：24
|
作者：
KENNEDY, GL [1 ]
GRAEPEL, GJ [1 ]
机构：
[1] WYETH AYERST LABS,RADNOR,PA
来源：
TOXICOLOGY LETTERS | 1991年 / 56卷 / 03期
关键词：
LD50; LC50; PREDICTIVE VALUE; ACUTE TOXICITY; ORAL; INHALATION;
D O I：
10.1016/0378-4274(91)90160-8
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
A survey of 108 chemicals was conducted to determine the relationship between acute oral and acute inhalation toxicity data in the rat. LD50 or LC50 values were compared after classification of each chemical in terms of relative toxicity. A positive correlation (0.53, P < 0.001) between the classification of toxicity for the oral and inhalation routes was determined. However, the magnitude of this correlation was such that the predictive value of one for the other was limited. For a complete acute toxicity profile, it does not appear as if the determination of acute toxicity by one of those routes would yield a reliable estimate of toxicity by the other route.
引用
收藏
页码：317 / 326
页数：10
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