PREVALENCE OF TRIANTENNARY AND TETRAANTENNARY GLYCANS OF HUMAN ALPHA-1-ACID GLYCOPROTEIN IN RELEASE OF MACROPHAGE INHIBITOR OF INTERLEUKIN-1 ACTIVITY

被引:70
作者
BORIES, PN
FEGER, J
BENBERNOU, N
ROUZEAU, JD
AGNERAY, J
DURAND, G
机构
[1] Laboratoire de Biochimie, Université Paris-Sud, Châtenay-Malabry, 92296
关键词
D O I
10.1007/BF00915815
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Based on the affinity for concanavalin A (Con A), human α1-acid glycoprotein (AGP) can be separated by chromatography on Con A-Sepharose gel into three variants: Con A unreactive AGP, Con A weakly reactive AGP, and Con A strongly reactive AGP. When exposed to native AGP or to its glycan variants, murine peritoneal macrophages released a factor that inhibited the interleukin-1 (IL-1) proliferative activity as measured in terms of the thymocyte comitogenic assay. Con A unreactive AGP, which contains tri- and tetraantennary glycans and no biantennae, proved to be more effective than Con A weakly and Con A strongly reactive variants, which contain one and two diantennary glycans, respectively. The inhibitory effect was not a function of the negative charge related to the sialyl residues and was not mediated by the maanosyl-fucosyl receptor. © 1990 Plenum Publishing Corporation.
引用
收藏
页码:315 / 323
页数:9
相关论文
共 18 条
[1]   EVIDENCE FOR UNIFORMITY OF THE CARBOHYDRATE CHAINS IN INDIVIDUAL GLYCOPROTEIN MOLECULAR VARIANTS [J].
BAYARD, B ;
KERCKAERT, JP .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 95 (02) :777-784
[2]   IMMUNOSUPPRESSION BY HUMAN-PLASMA ALPHA-1-ACID GLYCOPROTEIN - IMPORTANCE OF THE CARBOHYDRATE MOIETY [J].
BENNETT, M ;
SCHMID, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (10) :6109-6113
[3]   GLYCOSYLATION OF 3 MOLECULAR-FORMS OF HUMAN ALPHA-1-ACID GLYCOPROTEIN HAVING DIFFERENT INTERACTIONS WITH CONCANAVALIN-A - VARIATIONS IN THE OCCURRENCE OF DIANTENNARY, TRIANTENNARY, AND TETRAANTENNARY GLYCANS AND THE DEGREE OF SIALYLATION [J].
BIERHUIZEN, MFA ;
DEWIT, M ;
GOVERS, CARL ;
FERWERDA, W ;
KOELEMAN, C ;
POS, O ;
VANDIJK, W .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 175 (02) :387-394
[4]   ALTERATIONS IN THE CARBOHYDRATE MOIETY OF ALPHA-1-ACID GLYCOPROTEIN PURIFIED FROM HUMAN CIRRHOTIC ASCITIC FLUID [J].
BIOU, D ;
KONAN, D ;
FEGER, J ;
AGNERAY, J ;
LEROY, Y ;
CARDON, P ;
FOURNET, B ;
DURAND, G .
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 913 (03) :308-312
[5]   HUMAN ALPHA-1-ACID GLYCOPROTEIN-EXPOSED MACROPHAGES RELEASE INTERLEUKIN 1 INHIBITORY ACTIVITY [J].
BORIES, PN ;
GUENOUNOU, M ;
FEGER, J ;
KODARI, E ;
AGNERAY, J ;
DURAND, G .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 147 (02) :710-715
[6]  
CHERESH DA, 1984, IMMUNOLOGY, V51, P541
[7]  
CHIU KM, 1977, IMMUNOLOGY, V32, P997
[8]   POTENTIATION OF T-LYMPHOCYTE RESPONSE TO MITOGENS .1. RESPONDING CELL [J].
GERY, I ;
GERSHON, RK ;
WAKSMAN, BH .
JOURNAL OF EXPERIMENTAL MEDICINE, 1972, 136 (01) :128-&
[9]  
ISHIZAKA K, 1986, ADV IMMUNOPHARMACOL, P153
[10]   CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].
LAEMMLI, UK .
NATURE, 1970, 227 (5259) :680-+