Recent clinical trials in diabetes - implications for managing older patients

被引：0

作者：

Hawthorne, G. C. ^{[1
]}

Yarnall, A. J. ^{[2
]}

机构：

[1] Newcastle Gen Hosp, Diabetes Ctr, Newcastle Upon Tyne, Tyne & Wear, England

[2] Freeman Rd Hosp, Dept Care Elderly, Newcastle Upon Tyne, Tyne & Wear, England

来源：

REVIEWS IN CLINICAL GERONTOLOGY | 2009年 / 19卷 / 01期

关键词：

Diabetes mellitus; elderly; glycaemic targets; microvascular disease; macrovascular disease; ypoglycaemia; cognitive function;

D O I：

10.1017/S0959259809990104

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The prevalence of type 2 diabetes is set to increase, and with it the complications associated with diabetes. Since 2007 there have been a number of significant trials that may change the way we think about treating people with diabetes, especially our older patients. These trials include the Steno-2 trial, UKPDS legacy trial, ADVANCE, ACCORD and VADT. These trials are reviewed in detail in this article, including the implications for the patients we treat. Recent work assessing the effect of HbA1c on cognitive function and the effects of hypoglycaemia are also discussed. We conclude with suggestions for targets for glycated haemoglobin level based on NICE guidance.

引用

页码：25 / 33

页数：9

共 50 条

[31] Clinical trials and lipid guidelines for type II diabetes [J].

Prisant, LM .

JOURNAL OF CLINICAL PHARMACOLOGY, 2004, 44 (04) :423-430

[32] Consideration of older patients for enrollment in phase 1 clinical trials: Exploring treatment related toxicities and outcomes [J].

Buechel, Megan ;

McGinnis, Austin ;

Vesely, Sara K. ;

Wade, Katrina S. ;

Moore, Kathleen N. ;

Gunderson, Camille C. .

GYNECOLOGIC ONCOLOGY, 2018, 149 (01) :28-32

[33] Nonalcoholic Fatty Liver Disease and Implications for Older Adults with Diabetes [J].

Mantovani, Alessandro ;

Targher, Giovanni ;

Zoppini, Giacomo .

CLINICS IN GERIATRIC MEDICINE, 2020, 36 (03) :527-+

[34] Exclusion of Older Patients From Ongoing Clinical Trials for Hematological Malignancies: An Evaluation of the National Institutes of Health Clinical Trial Registry [J].

Hamaker, Marije E. ;

Stauder, Reinhard ;

van Munster, Barbara C. .

ONCOLOGIST, 2014, 19 (10) :1069-1075

[35] Managing hypertension in patients with type 2 diabetes mellitus [J].

Dobesh, Paul P. .

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2006, 63 (12) :1140-1149

[36] Managing type 1 diabetes mellitus in ambulatory patients [J].

Santoso, L ;

Mareels, IMY .

PROCEEDINGS OF THE 39TH IEEE CONFERENCE ON DECISION AND CONTROL, VOLS 1-5, 2000, :4859-4864

[37] The endocrinologist gap: Managing diabetes patients in absence of a specialist [J].

Ahmed, Nabeel ;

Ingelmo, Pablo .

PEDIATRIC ANESTHESIA, 2024, 34 (10) :1063-1066

[38] Horse-racing effect and clinical trials in older persons [J].

Cesari, Matteo ;

Canevelli, Marco .

FRONTIERS IN AGING NEUROSCIENCE, 2014, 6

[39] Hypoglycaemia in diabetes mellitus: epidemiology and clinical implications [J].

Frier, Brian M. .

NATURE REVIEWS ENDOCRINOLOGY, 2014, 10 (12) :711-722

[40] Discontinuation of Antihyperglycemic Therapy and Clinical Outcomes After Acute Myocardial Infarction in Older Patients With Diabetes [J].

Lipska, Kasia J. ;

Wang, Yongfei ;

Kosiborod, Mikhail ;

Masoudi, Frederick A. ;

Havranek, Edward P. ;

Krumholz, Harlan M. ;

Inzucchi, Silvio E. .

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 2010, 3 (03) :236-242

← 1 2 3 4 5 →