CHROMOSOMAL SENSITIVITY OF HUMAN-LYMPHOCYTES TO BLEOMYCIN - INFLUENCE OF ANTIOXIDANT ENZYME-ACTIVITIES IN WHOLE-BLOOD AND DIFFERENT BLOOD FRACTIONS

被引：18

作者：

BOLZAN, AD

BIANCHI, NO

LARRAMENDY, ML

BIANCHI, MS

机构：

[1] NATL UNIV LA PLATA, FAC CIENCIAS NAT, CITOGENET LAB, RA-1900 LA PLATA, ARGENTINA

[2] NATL UNIV LA PLATA, MUSEO LA PLATA, RA-1900 LA PLATA, ARGENTINA

[3] NATL UNIV LA PLATA, FAC CIENCIAS AGRON & FORESTALES, CATEDRA GENET & MEJORAMIENTO, RA-1900 LA PLATA, ARGENTINA

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 64卷 / 02期

关键词：

D O I：

10.1016/0165-4608(92)90342-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The activity of the antioxidant enzymes catalase (CAT), peroxidases (POD), and superoxide dismutases (SOD) in whole blood and different blood fractions was analyzed in 20 normal human beings and correlated with the chromosomal sensitivity of lymphocytes to bleomycin (BLM) (measured as frequency of dicentric chromosomes per BLM dose). Our results demonstrate that both the physioLogic Activities of the enzymes and the chromosomal sensitivity to BLM exhibit an ample and significant interindividual variability. An inverse and linear correlation between chromosomal sensitivity to BLM and the concentration of 1) CAT and POD in plasma and 2) SOD in whole blood, erythrocytes, and plasma was found. On the other hand, the chromosomal sensitivity to BLM showed a direct correlation with the concentration of SOD and POD in mononuclear leukocytes. It is suggested that a determination of antioxidant enzyme (AOE) activities in a given cell population may serve to predict the chromosomal sensitivity to BLM.

引用

页码：133 / 138

页数：6

共 28 条

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