LONG-TERM TOXICITY STUDIES IN RATS AND DOGS WITH THE ANTIARRHYTHMIC AGENT PIRMENOL HYDROCHLORIDE

Pirmenol HCl, a new antiarrhythmic, was studied for toxicity in rats and dogs following oral administration for 52 consecutive weeks. Dogs were given 5, 10 and 15 mg/kg twice daily whereas rats received 25, 50 and 100 mg/kg/day. Transient responses in dogs such as dry oral mucosa represented pharmacological reactions. Rats showed weight gain suppression and lowered food consumption; serum glucose was slightly reduced at 50 and 100 mg/kg. There were no overt drug-related changes in other parameters indicating that pirmenol HCl does not have detrimental effects on rats and dogs following long term administration.