DIFFERENTIAL RECOGNITION OF SECRETORY VESICLES BY ANNEXINS

被引：17

作者：

CREUTZ, CE

MOSS, S

EDWARDSON, JM

HIDE, I

GOMPERTS, B

SCHIAVO, G

NEVALAINEN, L

VONRUDEN, L

FLETCHER, L

BARTELS, F

WASCHULEWSKI, I

BUCCIONE, R

PINXTEREN, J

MAGNUS, C

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,W-3400 GOTTINGEN,GERMANY

[2] UNIV MANCHESTER,DEPT PHYSIOL SCI,MANCHESTER M13 9PL,LANCS,ENGLAND

[3] HANOVER MED SCH,W-3000 HANNOVER 61,GERMANY

[4] UNIV MARBURG,DEPT ANAT & CELL BIOL,W-3550 MARBURG,GERMANY

[5] UNIV INSTELLING ANTWERP,DEPT NEUROFARMACOL,B-2610 WILRIJK,BELGIUM

[6] UNIV VIRGINIA,DEPT PHARMACOL,CHARLOTTESVILLE,VA 22908

[7] UNIV CAMBRIDGE,DEPT PHARMACOL,CAMBRIDGE CB2 1QJ,ENGLAND

[8] IST PATOL GEN,PADUA,ITALY

[9] INST BIOTECHNOL,HELSINKI,FINLAND

[10] UNIV LONDON,SCH PHARM,DEPT PHARMACOL,LONDON,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91199-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interactions of synexin, calpactin, and p68 (annexins VII, II, and VI) with zymogen granules and adrenal medullary chromaffin granules were compared. Synexin promoted the aggregation and fusion of both types of organelles. Calpactin inhibited the action of synexin on zymogen granules but would aggregate only chromaffin granules. p68 inhibited aggregation of chromaffin granules by calpactin and fusion of zymogen granules by synexin. The results demonstrate that these annexins, all of which bind acidic phospholipids, interact differently with different biological membranes and therefore may play specific and non-overlapping roles in cells where they are coexpressed. © 1992.

引用

页码：347 / 352

页数：6

共 9 条

[1] CIS-UNSATURATED FATTY-ACIDS INDUCE THE FUSION OF CHROMAFFIN GRANULES AGGREGATED BY SYNEXIN [J].