COLORIMETRIC ACETAMINOPHEN DETERMINATION IN PHARMACEUTICAL FORMULATIONS

被引：11

作者：

BELAL, S

ELSAYED, MAH

ELWALIELY, A

ABDINE, H

机构：

[1] Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria

[2] Department of Pharmacy, University of Nigeria, Nsukka

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Acetaminophen—analysis; colorimetry; various pharmaceutical formulations; Analgesics—acetaminophen; analysis; Antipyretics—acetaminophen; Colorimetry—analysis; acetaminophen in various pharmaceutical formulations;

D O I：

10.1002/jps.2600680626

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Different approaches for the colorimetric determination of acetaminophen, based on its coupling with diazotized o‐nitroaniline, are described. Copper(II) chelation with the coupled compound makes the method highly selective. Sensitivity is increased when the acetaminophen assay is carried out indirectly through the determination of the chelate's copper content. Optimum conditions for performing the different approaches are described. The stoichiometric balance for the reactants in the coupled compound and chelate is determined. The degree of dissociation and the instability constant are computed. The rectilinear relationship between the absorbance of the different products and the concentration of acetaminophen allows for its determination in different pharmaceutical formulations. Compared with the official method, the proposed methods give more accurate results. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：750 / 753

页数：4

共 25 条

[1]

BROCKELT G, 1965, PHARMAZIE, V20, P136

[2]

DAVIES OL, 1972, STATISTICAL METHODS, P178

[3] COLORIMETRIC METHOD FOR DETERMINATION OF PHENACETIN AND PARACETAMOL .3. STUDIES OF INDOPHENOL REACTION - ALTERNATIVE MANUAL PROCEDURE FOR DETERMINATION OF PHENACETIN AND PARACETAMOL AND ITS APPLICATION TO DETERMINATION OF OTHER PHARMACEUTICALS, INCLUDING SULFONAMIDES, PROCAINE AND RELATED COMPOUNDS [J].