T4-DNA TOPOISOMERASE - NEW ATP-DEPENDENT ENZYME ESSENTIAL FOR INITIATION OF BACTERIOPHAGE-T4 DNA-REPLICATION

被引：237
作者：
LIU, LF
LIU, CC
ALBERTS, BM
机构：
[1] Department of Biochemistry and Biophysics, University of California, San Francisco
来源：
NATURE | 1979年 / 281卷 / 5731期
关键词：
D O I：
10.1038/281456a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo. © 1979 Nature Publishing Group.
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页码：456 / 461
页数：6
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