ANTIGEN PRESENTATION REQUIRES TRANSPORT OF MHC CLASS-1 MOLECULES FROM THE ENDOPLASMIC-RETICULUM

被引：176

作者：

COX, JH ^{[1
]}

YEWDELL, JW ^{[1
]}

EISENLOHR, LC ^{[1
]}

JOHNSON, PR ^{[1
]}

BENNINK, JR ^{[1
]}

机构：

[1] GEORGETOWN UNIV,DEPT MOLEC VIROL & IMMUNOL,ROCKVILLE,MD 20852

来源：

SCIENCE | 1990年 / 247卷 / 4943期

关键词：

D O I：

10.1126/science.2137259

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of exocytosis of major histocompatibility complex (MHC) class I molecules in the presentation of antigens to mouse cytotoxic T lymphocytes (CTLs) was examined by use of a recombinant vaccinia virus that expresses the E19 glycoprotein from adenovirus. E19 blocked the presentation of vaccinia and influenza virus proteins to CTLs in a MHC class I allele-specific manner identical to its inhibition of MHC class I transport from the endoplasmic reticulum. This finding indicates that (i) the relevant parameter for antigen presentation is the rate of MHC class I molecule exocytosis, not the level of class I cell surface expression, and (ii) association of class I molecules with antigen is likely to occur within the endoplasmic reticulum.

引用

页码：715 / 718

页数：4

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