IDENTIFICATION OF THE ARG-GLY-ASP SEQUENCE IN LAMININ-A CHAIN AS A LATENT CELL-BINDING SITE BEING EXPOSED IN FRAGMENT P1

被引：126
作者：
AUMAILLEY, M
GERL, M
SONNENBERG, A
DEUTZMANN, R
TIMPL, R
机构：
[1] NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,AMSTERDAM,NETHERLANDS
[2] UNIV AMSTERDAM,EXPTL & CLIN IMMUNOL LAB,AMSTERDAM,NETHERLANDS
[3] UNIV REGENSBURG,BIOCHEM MICROBIOL & GENET LAB,W-8400 REGENSBURG,GERMANY
来源：
FEBS LETTERS | 1990年 / 262卷 / 01期
关键词：
Basement membrane; Cell attachment; Integrin; Proteolytic fragment; Synthetic peptide;
D O I：
10.1016/0014-5793(90)80159-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A single RGD-containing sequence present within an epidermal growth factor-like repeat of the short arms of laminin is shown by peptide inhibition to block integrin receptors recognizing a latent cell-binding site of laminin. Based on proteolysis data it is proposed that masking occurs by folding of the globular domain IVa over the cell-binding site in the adjacent rod-like structures of laminin A chain. © 1990.
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页码：82 / 86
页数：5
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