CLINICAL GOAL IN SIGHT FOR SMALL MOLECULE RENIN INHIBITORS

被引:26
作者
BOGER, J
机构
关键词
D O I
10.1016/0165-6147(87)90093-9
中图分类号
R9 [药学];
学科分类号
1007 ;
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页码:370 / 372
页数:3
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共 20 条
[1]  
BOCK MG, 1985, PEPTIDES STRUCTURE F, P751
[2]  
BOGER J, 1985, REGUL PEPTIDES, P8
[3]  
BOGER J, 1985, ANNU REP MED CHEM, V20, P257
[4]   NOVEL RENIN INHIBITORS CONTAINING THE AMINO-ACID STATINE [J].
BOGER, J ;
LOHR, NS ;
ULM, EH ;
POE, M ;
BLAINE, EH ;
FANELLI, GM ;
LIN, TY ;
PAYNE, LS ;
SCHORN, TW ;
LAMONT, BI ;
VASSIL, TC ;
STABILITO, II ;
VEBER, DF ;
RICH, DH ;
BOPARI, AS .
NATURE, 1983, 303 (5912) :81-84
[5]   RENIN INHIBITORS - SYNTHESES OF SUBNANOMOLAR, COMPETITIVE, TRANSITION-STATE ANALOG INHIBITORS CONTAINING A NOVEL ANALOG OF STATINE [J].
BOGER, J ;
PAYNE, LS ;
PERLOW, DS ;
LOHR, NS ;
POE, M ;
BLAINE, EH ;
ULM, EH ;
SCHORN, TW ;
LAMONT, BI ;
LIN, TY ;
KAWAI, M ;
RICH, DH ;
VEBER, DF .
JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) :1779-1790
[6]   HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES [J].
FOUNDLING, SI ;
COOPER, J ;
WATSON, FE ;
CLEASBY, A ;
PEARL, LH ;
SIBANDA, BL ;
HEMMINGS, A ;
WOOD, SP ;
BLUNDELL, TL ;
VALLER, MJ ;
NOREY, CG ;
KAY, J ;
BOGER, J ;
DUNN, BM ;
LECKIE, BJ ;
JONES, DM ;
ATRASH, B ;
HALLETT, A ;
SZELKE, M .
NATURE, 1987, 327 (6120) :349-352
[7]  
HABER E, 1985, J HYPERTENS, V3, pS71
[8]  
KOKUBU T, 1986, HYPERTENSION, V8, P1
[9]  
MIYAZAKI M, 1986, 106TH ANN M PHARM SO, V40, pP70
[10]   AN ORALLY ACTIVE INHIBITOR OF RENIN [J].
PALS, DT ;
THAISRIVONGS, S ;
LAWSON, JA ;
KATI, WM ;
TURNER, SR ;
DEGRAAF, GL ;
HARRIS, DW ;
JOHNSON, GA .
HYPERTENSION, 1986, 8 (12) :1105-1112