DNA-PLOIDY AND S-PHASE FRACTION IN PRIMARY MELANOMAS AND THEIR REGIONAL METASTASES

被引:13
作者
KARLSSON, M
BOERYD, B
CARSTENSEN, J
KAGEDAL, B
WINGREN, S
机构
[1] Departments of oncology university hospital, Departments of pathology university hospital, Departments of clinical chemistry university hospital, Department of Health and Society, Tema research institute linkoping university, linkoping, NY
关键词
DNA PLOIDY; MELANOMA METASTASES; PRIMARY MELANOMA; S-PHASE;
D O I
10.1097/00008390-199402000-00007
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Flow cytometric analysis of DNA ploidy and S-phase fraction was performed on the primary melanomas and the first metastases from 55 melanoma patients with regional lymph node metastases or in transit metastases. The frequency of aneuploidy was significantly higher in metastases than in the primary tumour (p = 0.009), suggesting a higher growth potential in melanoma metastases than in the primary tumours. In 18 patients with reliable S-phase determinations from both primary tumour and metastasis there was no significant difference in mean S-phase fraction between primary melanomas and metastases. Skin metastases localized in dermis and subcutis had a significantly (p = 0.012) higher mean S-phase fraction than lymph node metastases.
引用
收藏
页码:47 / 51
页数:5
相关论文
共 22 条
  • [1] Bartkowiak D., Schumann J., Otto F.J., Lippold A., Drepper H., DNA flow cytometry in the prognosis of primary malignant melanoma, Oncology, 48, pp. 39-43, (1991)
  • [2] Bines S.D., Vonroenn J.H., Kheir S.M., Coon J.S., Flow cytometry in melanoma, Nathanson L, pp. 155-169, (1988)
  • [3] Kheir S.M., Bines S.D., Vonroenn J.H., Soong S.J., Urist M.M., Coon J.S., Prognostic significance of DNA aneuploidy in stage I cutaneous melanoma, Ann Surg, 207, pp. 455-461, (1988)
  • [4] S0ndergaard K., Larsen J.K., Moller U., Christensen I.J., Hou-Jensen K., DNA ploidy-characteristics of human malignant melanoma analysed by flow cytometry and compared with histology and clinical course, Virchows Arch (Cell Pathol), 42, pp. 43-52, (1983)
  • [5] Muhonen T., Pyrhonen S., Laasonen A., Asko-Seljavaara S., Franssila K., DNA aneuploidy and low S-phase fraction as favourable prognostic signs in metastatic melanoma, Br J Cancer, 64, pp. 749-752, (1991)
  • [6] Bartkowiak D., Otto F., Schumann J., Lippold A., Drepper H., Sequential D., Flow cytometry in metastatic malignant melanoma, Oncology, 48, pp. 154-157, (1991)
  • [7] Hansson J., Tribukait B., Lewensohn R., Ringborg U., Flow Cytofluorometric DNA analyses of metastases of human malignant melanomas, Anal Quant Cytol, 4, pp. 99-104, (1982)
  • [8] Zaloudik J., Moore M., Ghosh A.K., Mechl Z., Rejthar A., DNA content and MHC class II antigen expression in malignant melanoma: Clinical course, J Clin Pathol, 41, pp. 1078-1084, (1988)
  • [9] Karlsson M., Boeryd B., Carstensen J., Et al., DNA ploidy and S-phase in primary malignant melanoma as prognostic factors for stage III disease, Br J Cancer, 67, pp. 134-138, (1993)
  • [10] Schutte B., Reynders M., Bosman F.T., Blijham G.H., Flow cytometric determination of DNA ploidy level in nuclei isolated from paraffin-embedded tissue, Cytometry, 6, pp. 26-30, (1985)