PARANEOPLASTIC INTESTINAL PSEUDOOBSTRUCTION ASSOCIATED WITH HIGH TITERS OF HU AUTOANTIBODIES

被引：42
作者：
CONDOM, E
VIDAL, A
ROTA, R
GRAUS, F
DALMAU, J
FERRER, I
机构：
[1] HOSP PRINCIPES ESPANA,SERV ANAT PATOL,UNIDAD NEUROPATOL,E-08907 LHOSPITALET LLOBR,SPAIN
[2] HOSP PRINCIPES ESPANA,SERV GASTROENTEROL,LHOSPITALET LLOBR,SPAIN
[3] HOSP CLIN BARCELONA,SERV NEUROL,E-08036 BARCELONA,SPAIN
[4] MEM SLOAN KETTERING CANC CTR,DEPT NEUROL,NEW YORK,NY 10021
来源：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1993年 / 423卷 / 06期
关键词：
SMALL-CELL LUNG CANCER; PARANEOPLASTIC ENCEPHALOMYELITIS/SENSORY NEURONOPATHY; PSEUDOOBSTRUCTION; VISCERAL NEURONOPATHY; HU ANTIGEN/ANTIBODY;
D O I：
10.1007/BF01606543
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudoobstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC.
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页码：507 / 511
页数：5
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