OXIDIZED GLUTATHIONE IS INCREASED IN THE ALVEOLAR FLUID OF PATIENTS WITH THE ADULT-RESPIRATORY-DISTRESS-SYNDROME

被引：172
作者：
BUNNELL, E [1 ]
PACHT, ER [1 ]
机构：
[1] OHIO STATE UNIV,DEPT INTERNAL MED,DIV PULM & CRIT CARE,COLUMBUS,OH
来源：
AMERICAN REVIEW OF RESPIRATORY DISEASE | 1993年 / 148卷 / 05期
关键词：
D O I：
10.1164/ajrccm/148.5.1174
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The adult respiratory distress syndrome (ARDS) is a devastating clinical illness characterized by refractory hypoxemia and high-permeability pulmonary edema. Reactive oxygen species may play a key role in the pathogenesis of the acute lung injury. Glutathione is a tripeptide that is able to react with and effectively neutralize oxidants, such as hydrogen peroxide. The present study found that the alveolar epithelial lining fluid of patients with ARDS was deficient in total glutathione compared with that of normal subjects (31.5 +/- 8.4 versus 651.0 +/- 103.1 mu M, p = 0.0001) and patients with cardiogenic pulmonary edema (31.5 +/- 8.4 versus 154.1 +/- 52.4 mu M, p = 0.001). In addition, a greater percentage of total glutathione was in the oxidized form in patients with ARDS compared with normal subjects (30.6 +/- 6.1 versus 6.4 +/- 2.9%, p = 0.03). This deficiency of reduced glutathione in the alveolar fluid may predispose these patients to enhanced lung cell injury.
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页码：1174 / 1178
页数：5
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