CYTOTOXICITY OF MICROGLIA

被引：931

作者：

BANATI, RB ^{[1
]}

GEHRMANN, J ^{[1
]}

SCHUBERT, P ^{[1
]}

KREUTZBERG, GW ^{[1
]}

机构：

[1] MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,AM KLOPFERSPITZ 18A,W-8033 MARTINSRIED,GERMANY

来源：

GLIA | 1993年 / 7卷 / 01期

关键词：

FREE OXYGEN RADICALS; NITRIC OXIDE; CYTOKINES; PHAGOCYTOSIS; PROTEINASES; CATHEPSINS;

D O I：

10.1002/glia.440070117

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The most characteristic property of microglia is their swift activation in response to neuronal stress and their capacity for site-directed phagocytosis. The transformation of microglia into intrinsic brain macrophages appears to be under strict control and takes place if neuronal and/or terminal degeneration occurs in response to nerve lesion. The differentiation of microglia into brain macrophages is accompanied by the release of several secretory products, e.g., proteinases, cytokines, reactive oxygen intermediates, and reactive nitrogen intermediates. Interference with the microglial activation or the productions of cytotoxic metabolites by microglia may thus offer new therapeutic opportunities for the prevention of neuronal cell death in CNS disease.

引用

页码：111 / 118

页数：8

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