ANGIOTENSIN-II AND FLUID INGESTION IN OLD RATS

被引：23
|
作者：
SILVER, AJ [1 ]
MORLEY, JE [1 ]
ISHIMARUTSENG, TV [1 ]
MORLEY, PMK [1 ]
机构：
[1] ST LOUIS DEPT VET AFFAIRS,CTR GERIATR RES EDUC & CLIN,ST LOUIS,MO 63104
来源：
NEUROBIOLOGY OF AGING | 1993年 / 14卷 / 06期
关键词：
AGING; FLUID INGESTION; ANGIOTENSIN II;
D O I：
10.1016/0197-4580(93)90033-8
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Fluid ingestion was studied in Fischer 344/Brown Norway F1 rats aged 3; 12, 20, and 24 months of age. There was an age-related decrease in fluid ingestion when fluid intake was measured over 24 h. After water deprivation, 24- and 20-month-old rats drank less than 3- and 12-month-old rats. Twelve, 20-, and 24-month-old rats had less fluid intake associated with food deprivation than did 3-month-old rats. Three month old rats drank more fluid after angiotensin II than did 12-, 20-, and 24-month-old rats when expressed as fluid intake per kg body weight. These studies confirm that the rat is a reasonable model to study age-related hypodipsia.
引用
收藏
页码：519 / 522
页数：4
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