EVALUATION OF POLY(ISOBUTYLCYANOACRYLATE) NANOPARTICLES FOR MUCOADHESIVE OCULAR DRUG-DELIVERY .1. EFFECT OF FORMULATION VARIABLES ON PHYSICOCHEMICAL CHARACTERISTICS OF NANOPARTICLES

被引：26

作者：

DAS, SK

TUCKER, IG

HILL, DJT

GANGULY, N

机构：

[1] UNIV QUEENSLAND,DEPT PHARM,BRISBANE,QLD 4029,AUSTRALIA

[2] MEM UNIV NEWFOUNDLAND,SCH PHARM,ST JOHNS,NF A1B 3X5,CANADA

[3] UNIV OTAGO,SCH PHARM,DUNEDIN,NEW ZEALAND

[4] UNIV QUEENSLAND,DEPT CHEM,ST LUCIA,QLD 4067,AUSTRALIA

[5] UNIV PITTSBURGH,SCH PHARM,PITTSBURGH,PA 15260

来源：

PHARMACEUTICAL RESEARCH | 1995年 / 12卷 / 04期

关键词：

OCULAR DRUG DELIVERY; NANOPARTICLES; POLY(ISOBUTYLCYANOACRYLATE); PHYSICOCHEMICAL CHARACTERIZATION;

D O I：

10.1023/A:1016249812466

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A factorial design was applied to evaluate the effect of formulation variables on physicochemical properties of poly(isobutylcyanoacrylate) nanoparticles. Formulation variables were dextran T40 or T70 and Pluronic(TM) F68 or Tween(TM) 20 acting as stabilizer and surfactant respectively, and three pH levels (2, 4 and 7). Nanoparticles possessed unimodal particle size distribution with significant effect of dextran, surfactant and pH. A wide range of molecular weight distribution was observed with significant effect of pH, and dextran on average molecular weight. NMR studies revealed the presence of dextran, monomer and surfactants in the nanoparticles. Solid state surface analysis using X-ray photoelectron spectroscopy confirmed the presence of three chemical environments to the carbon envelope, O - C = O,C - O/C = N and C - C.

引用

页码：534 / 540

页数：7

共 25 条

[1]

Huges P.M., Mitra A.K., Overview of Ocular Drug Delivery and Iatrogenic Ocular Cytopathologies, Ophthalmic Drug Delivery Systems, pp. 1-27, (1993)

[2]

Kreuter J., Nanoparticles as Bioadhesive Ocular Drug Delivery Systems, Bioadhesive Drug Delivery Systems, (1990)

[3]

Couvreur P., Polyalkylcyanoacrylates as colloidal drug carriers, Critical Reviews in Therapeutics Drug Carrier Systems, 5, pp. 1-20, (1988)

[4]

Harmia T., Speiser P.P, Kreuter J., Optimization of Pilocarpine Loading onto Nanoparticles by Sorption Procedure, Int. J. Pharm., 33, pp. 45-54, (1986)

[5]

Hui H., Robinson J., Ocular Delivery of Progesterone using a Bioadhesive Polymer, Int. J. Pharm., 26, pp. 203-213, (1985)

[6]

Wood R.W., Li V.H.K., Kreuter J., Robinson J.R., Ocular Disposition of Poly-hexyl-2-cyano[3-<sup>14</sup>C]acrylate Nanoparticles in the Albino Rabbit, Int. J. Pharm., 23, pp. 175-183, (1985)

[7]

Zimmer A., Kreuter J., Robinson J.R., Studies on the Transport Pathway of PBCA Nanoparticles in Ocular Tissues, J. Microencapsulation., 8, pp. 497-504, (1991)

[8]

Birrenbach G., Speiser P.P., Polymerized Micelles and their use as an Adjuvents in Immunology, J. Pharm. Sci., 65, pp. 1763-1766, (1976)

[9]

Kreuter J., Speiser P.P., In Vitro Studies of Poly(methyl Methacrylate) Adjuvents, J. Pharm. Sci., 65, pp. 1624-1627, (1976)

[10]

Davis S.S., Illum L., The Targeting of Drugs using Polymeric Microspheres, British Polymer Journal, 15, pp. 160-164, (1983)

← 1 2 3 →