ASSESSING GENETIC-BASED THERAPIES FOR AIDS USING THE SIMIAN IMMUNODEFICIENCY VIRUS

被引：2
作者：
ENDRES, CL
BERGQUAM, E
AXTHELM, MK
WONG, SW
机构：
[1] OREGON REG PRIMATE RES CTR,DIV PATHOBIOL & IMMUNOL,BEAVERTON,OR 97006
[2] OREGON HLTH SCI UNIV,DEPT MOLEC MICROBIOL & IMMUNOL,PORTLAND,OR 97201
来源：
JOURNAL OF MEDICAL PRIMATOLOGY | 1995年 / 24卷 / 03期
关键词：
SIV; RETROVIRUS; GENE THERAPY; ANTIVIRAL; TRANSIENT TRANSFECTION; HIV;
D O I：
10.1111/j.1600-0684.1995.tb00159.x
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
A plasmid encoding the full-length infectious molecular proviral clone of SIVmac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4(+) cell lines and primary rhesus macaque peripheral blood mononuclear cells. Since replication of SIV requires the functional expression of the viral encoded rev protein, transient co-transfection studies were initiated with the infectious proviral clone and a well-characterized trans-dominant negative HIV-1 rev mutant.
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页码：141 / 144
页数：4
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