THE NERVE GROWTH-FACTOR RECEPTOR - A MULTICOMPONENT SYSTEM THAT MEDIATES THE ACTIONS OF THE NEUROTROPHIN FAMILY OF PROTEINS

被引：78
|
作者：
BARKER, PA [1 ]
MURPHY, RA [1 ]
机构：
[1] UNIV ALBERTA, DEPT ANAT & CELL BIOL, EDMONTON T6G 2H7, ALBERTA, CANADA
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1992年 / 110卷 / 01期
关键词：
NEUROTROPHINS; TRK; NGF; BDNF; NT-3; TRUNCATED RECEPTOR;
D O I：
10.1007/BF02385000
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) are members of a family of structurally related proteins termed neurotrophins that promote the growth and survival of neurons in the central and peripheral nervous systems. Each of these proteins bind to at least two membrane receptors. One is the low affinity nerve growth factor receptor (p75), which binds each member of the neurotrophin family. The other is one of a family of tyrosine kinase receptors-trkA binds only NGF, the related trkB receptor binds BDNF and NT-3, and trkC binds NT-3 alone. This article reviews kinetic and biochemical information on p75 and its relationship to the trk gene products.
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页码：1 / 15
页数：15
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