INFLUENCE OF ACETYLSALICYLIC-ACID AND OF SALICYLIC-ACID ON MEDIATORS OF IMMUNE-RESPONSE

被引：0
|
作者：
PUGLIESE, A
MAGGIOLO, F
TORRE, D
FORNO, B
POLLONO, AM
MARTELLI, ML
BIGLINO, A
机构：
[1] UNIV TURIN,INST INFECT DIS,I-10124 TURIN,ITALY
[2] BAYER ITALY SPA,DEPT MED,MILAN,ITALY
[3] GEN HOSP E ES MACCHI FDN,DIV INFECT DIS,VARESE,ITALY
来源：
INTERNATIONAL JOURNAL OF IMMUNOTHERAPY | 1991年 / 7卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study it was attempted to determine the influence of acetylsalicylic acid (ASA) and its desacetylated metabolite (SA) on IL-2, alpha-IFN and gamma-IFN production as well as on PBMC proliferation. Neither compound was found to alter PBMC mitogen-stimulated proliferation or alpha-IFN and gamma-IFN production. ASA, but not SA, significantly increased in vitro production of IL-2. This effect was dose independent within the therapeutic range and was confirmed by ex vivo experiments. The use of ASA as symptomatic therapy for infectious diseases does not interfere with the host immune response and the potential usefulness of ASA as an immunomodulator can be postulated.
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页码：31 / 35
页数：5
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