THE MYOCARDIAL DEPRESSANT EFFECT OF VOLATILE ANESTHETICS DOES NOT INVOLVE ARACHIDONIC-ACID METABOLITES OR PERTUSSIS TOXIN-SENSITIVE G-PROTEINS

被引：7

作者：

VULLIEMOZ, Y ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT PHARMACOL,NEW YORK,NY 10032

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 203卷 / 03期

关键词：

ANESTHETICS (VOLATILE); HALOTHANE; ISOFLURANE; ARACHIDONIC ACID CASCADE; G-PROTEINS; MYOCARDIAL CONTRACTILITY; (RAT);

D O I：

10.1016/0014-2999(91)90889-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The involvement of the phospholipid-arachidonic acid pathway and of a pertussis toxin-sensitive G protein in the myocardial depressant effect of volatile anesthetics was examined in the rat heart left papillary muscle and atria. Neither phospholipase A2, cyclooxygenase or lipoxygenase antagonists altered the potency or the efficacy of clinically used concentrations of halothane and isoflurane in decreasing the contractile force of the muscles. Pretreatment of the rats with pertussis toxin (50-mu-g/kg i.v., 72 h before sacrifice), which abolished the myocardial depressant effect of muscarinic agonists, did not prevent the decrease in contractile force induced by the anesthetics. The results of this study indicate that the cellular mechanism of the myocardial depressant effect of volatile anesthetics does not involve a metabolite of the phospholipid-arachidonic acid pathway, does not require a functional pertussis toxin-sensitive G protein, and differs from that of muscarinic agonists.

引用

页码：345 / 351

页数：7