ALTERED CELL FATE IN LICL-TREATED SEA-URCHIN EMBRYOS

被引：43
作者：
NOCENTEMCGRATH, C [1 ]
MCISAAC, R [1 ]
ERNST, SG [1 ]
机构：
[1] TUFTS UNIV,DEPT BIOL,MEDFORD,MA 02155
来源：
DEVELOPMENTAL BIOLOGY | 1991年 / 147卷 / 02期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/0012-1606(91)90302-J
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Endo16 is a lineage-specific protein expressed during embryogenesis in the sea urchin, Strongylocentrotus purpuratus. We have examined the effects of various concentrations of lithium chloride, a well-known vegetalizing agent, on Endo16 expression in whole sea urchin embryos. Our results show that treatment with LiCl causes increased steady-state levels of Endo16 transcripts. An increase in the number of endodermal cells in treated embryos demonstrates a change in cell lineage. In addition, we observed a delay in development of lithium-treated embryos that is accompanied by a delay in the expression of a late class histone H2B gene. © 1991.
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页码：445 / 450
页数：6
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