C-BANDING STUDIES IN VARIOUS BLOOD DISORDERS

被引：40

作者：

BERGER, R ^{[1
]}

BERNHEIM, A ^{[1
]}

LECONIAT, M ^{[1
]}

VECCHIONE, D ^{[1
]}

机构：

[1] CNRS,F-75005 PARIS,FRANCE

来源：

CANCER GENETICS AND CYTOGENETICS | 1979年 / 1卷 / 02期

关键词：

D O I：

10.1016/0165-4608(79)90015-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A C-banding pattern study has been performed on 70 patients having Philadelphia chromosome-positive chronic myeloid leukemia (CML), 35 with polycythemia vera, 21 with myeloid metaplasias, 40 with acute myeloblastic leukemia (AML) as well as on 70 controls. The length of the C blocks were classified into five levels by comparison with the short arm of chromosome 16, using Patil and Lubs proposals. A significant difference in the distribution of C-band levels of chromosome 1 and an excess of asymmetrical pairs were found for CML compared with the controls. An abnormal distribution of chromosome 9 C variants were also found in blood disorder patients compared with the controls. In CML patients a random distribution of C variants between 9q+ and 9 were found. For the chromosome 16 a significant difference was found concerning the intrapair asymmetry distribution in AML compared with controls. © 1979.

引用

页码：95 / 102

页数：8

共 14 条

[1] PERICENTRIC INVERSION OF CHROMOSOME 1 - FREQUENCY AND POSSIBLE ASSOCIATION WITH CANCER [J].