FUNCTIONAL-SIGNIFICANCE OF ANTIBODY-FORMATION AFTER LONG-TERM SALMON-CALCITONIN THERAPY

被引：28

作者：

HOSKING, DJ

DENTON, LB

CADGE, B

MARTIN, TJ

机构：

[1] UNIV SHEFFIELD,DEPT CHEM PATHOL,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

[2] HARLOW WOOD ORTHOPAED HOSP,MANSFIELD,ENGLAND

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 03期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb02078.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Twenty patients with Paget's disease were challenged with porcine (PCT) and salmon (SCT) calcitonin before and after 6 months SCT therapy. Acute hypocalcaemia was clearly related to the prevailing rate of bone turnover but responses to PCT showed that treatment had not disturbed this relationship. Although antibodies to SCT developed in eight patients during the period of treatment the acute hypocalcaemic response to SCT was not diminished in relation to bone turnover. It is suggested that antibodies which develop during the course of SCT therapy do not necessarily exert a functionally effective neutralizing action. Copyright © 1979, Wiley Blackwell. All rights reserved

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页码：243 / 252

页数：10

相关论文

共 23 条

[1] VARIATION IN PLASMA CALCIUM WITH INDUCED CHANGES IN PLASMA SPECIFIC GRAVITY, TOTAL PROTEIN, AND ALBUMIN [J].

BERRY, EM ;

GUPTA, MM ;

TURNER, SJ ;

BURNS, RR .

BMJ-BRITISH MEDICAL JOURNAL, 1973, 4 (5893) :640-643

[2]

BIJVOET OLM, 1968, LANCET, V1, P876

[3]

BURKHARDT PM, 1973, CLIN ENDOCRINOL, V2, P15

[4] RESPONSE OF PAGETS-DISEASE TO PORCINE AND SALMON CALCITONINS - EFFECTS OF LONG-TERM TREATMENT [J].

DEROSE, J ;

SINGER, FR ;

AVRAMIDES, A ;

FLORES, A ;

DZIADIW, R ;

BAKER, RK ;

WALLACH, S .

AMERICAN JOURNAL OF MEDICINE, 1974, 56 (06) :858-866

[5] CALCIUM LOWERING EFFECT OF SYNTHETIC HUMAN, PORCINE, AND SALMON CALCITONIN IN PATIENTS WITH PAGETS-DISEASE [J].

GALANTE, L ;

JOPLIN, GF ;

MACINTYRE, I ;

WOODHOUSE, NJ .

CLINICAL SCIENCE, 1973, 44 (06) :605-610

[6] ACUTE RESPONSE TO CALCITONIN IN PAGETS-DISEASE - ITS RELATIONSHIP TO SERUM ALKALINE-PHOSPHATASE LEVEL AND EFFECT OF PHOSPHATE TREATMENT [J].

GERSHBERG, H ;

GIRGIS, M ;

GOLDBERG, L ;

DUGA, J ;

STPAUL, H .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1973, 36 (04) :691-696

[7] TREATMENT OF PAGETS-DISEASE OF BONE WITH SYNTHETIC HUMAN CALCITONIN - BIOCHEMICAL AND ROENTGENOLOGIC CHANGES [J].

GREENBERG, PB ;

DOYLE, FH ;

FISHER, MT ;

HILLYARD, CJ ;

JOPLIN, GF ;

PENNOCK, J ;

MACINTYRE, I .

AMERICAN JOURNAL OF MEDICINE, 1974, 56 (06) :867-870

[8] CALCITONIN RESISTANCE - CLINICAL AND IMMUNOLOGICAL STUDIES IN SUBJECTS WITH PAGETS-DISEASE OF BONE TREATED WITH PORCINE AND SALMON CALCITONINS [J].

HADDAD, JG ;

CALDWELL, JG .

JOURNAL OF CLINICAL INVESTIGATION, 1972, 51 (12) :3133-+

[9] OPTIMAL CONDITIONS FOR DETERMINATION OF SERUM ALKALINE PHOSPHATASE BY A NEW KINETIC METHOD [J].

HAUSAMEN, TU ;

HELGER, R ;

RICK, W ;

GROSS, W .

CLINICA CHIMICA ACTA, 1967, 15 (02) :241-&

[10] PREPARATION OF IODINE-131 LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC ACTIVITY [J].

HUNTER, WM ;

GREENWOOD, FC .

NATURE, 1962, 194 (4827) :495-&