Toxicity of Five Herbs in Aconitum L. on Tetrahymena thermophila Based on Spectrum-effect Relationship

被引：3

作者：

Sun, Xiao-jiao ^{[1
,2
]}

Liu, Tian-tian ^{[1
,2
]}

Zhao, Yan-ling ^{[2
]}

Zou, Wen-jun ^{[1
]}

Wang, Jia-bo ^{[2
]}

Liu, Shu-xian ^{[1
]}

Sun, Zhi-yong ^{[1
,2
]}

Li, Rui-sheng ^{[3
]}

Zhou, Xu ^{[4
]}

Gong, Man ^{[4
]}

Wang, Rui-lin ^{[4
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Sichuan, Peoples R China

[2] 302 Hosp Peoples Liberat Army, China Mil Inst Chinese Med, Beijing 100039, Peoples R China

[3] 302 Hosp Peoples Liberat Army, Anim Lab Ctr, Beijing 100039, Peoples R China

[4] 302 Hosp Peoples Liberat Army, Dept Integrat Med Ctr, Beijing 100039, Peoples R China

来源：

CHINESE HERBAL MEDICINES | 2014年 / 6卷 / 01期

关键词：

Aconitum L. herbal medicines; microcalorimetry; spectrum-effect relationships; Tetrahymena thermophila; ultra-high performance liquid chromatography;

D O I：

10.1016/S1674-6384(14)60003-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Objective To explore the active components with toxic effects in five Aconitum L. herbal medicines on Tetrahymena thermophila. Methods The fingerprints of five Aconitum L. herbal medicines were established by ultra-high performance liquid chromatography (UPLC) and the toxicity was evaluated by using a TAM Air Isothermal Calorimeter on Tetrahymena thermophila SB110. Results By analyzing the spectrum-effect relationships between UPLC fingerprints and toxic effects, the active components which had the toxic effects were obtained. Conclusion This work provides a general model of the combination of UPLC and microcalorimetry to study the spectrum-effect relationships of the five Aconitum L. herbal medicines, which could be used to evaluate the toxic effects and analyze the principal toxic components of the five Aconitum L. herbal medicines. On the whole, this result provides the experimental basis for the safe use of the five Aconitum L. herbal medicines in clinic.

引用

页码：29 / 35

页数：7

共 50 条

[1] Toxicity of Five Herbs in Aconitum L. on Tetrahymena thermophila Based on Spectrum-effect Relationship
Xiaojiao Sun
Tiantian Liu
Yanling Zhao
Wenjun Zou
Jiabo Wang
Shuxian Liu
Zhiyong Sun
Ruisheng Li
Xu Zhou
Man Gong
Ruilin Wang
Chinese Herbal Medicines, 2014, (01) : 29 - 35
[2] Toxicity of Five Herbs in Aconitum L. on Tetrahymena thermophila Based on Spectrum-effect Relationship
Xiao-jiao Sun
Tian-tian Liu
Yan-ling Zhao
Wen-jun Zou
Jia-bo Wang
Shu-xian Liu
Zhi-yong Sun
Rui-sheng Li
Xu Zhou
Man Gong
Rui-lin Wang
Chinese Herbal Medicines, 2014, 6 (01) : 29 - 35
[3] Spectrum-effect relationships between UPLC fingerprints and bioactivities of five Aconitum L. plants
Sun, Zhiyong
Zhao, Yanling
Liu, Tiantian
Sun, Xiaojiao
Li, Ruisheng
Zhang, Ping
Xiao, Xiaohe
THERMOCHIMICA ACTA, 2013, 558 : 61 - 66
[4] The Study of Spectrum-Effect Relationship Based on Grey Relational Degree
Zhao, Yue
Zhang, Xiaoqin
INTERNATIONAL SYMPOSIUM ON SIGNAL PROCESSING BIOMEDICAL ENGINEERING, AND INFORMATICS (SPBEI 2013), 2014, : 751 - 758
[5] Exploring anti-inflammatory and antioxidant-related quality markers of Artemisia absinthium L. based on spectrum-effect relationship
Wubuli, Ayixiamuguli
Abdulla, Rahima
Zhao, Jiangyu
Wu, Tao
Aisa, Haji Akber
PHYTOCHEMICAL ANALYSIS, 2024, 35 (05) : 1152 - 1173
[6] Spectrum-effect relationship between UPLC fingerprints and melanogenic effect of Ruta graveolens L
Wubuli, Ayixiamuguli
Abdulla, Rahima
Zang, Deng
Jiang, Lan
Chen, Longyi
Aisa, Haji Akber
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2023, 1221
[7] Discovering the Major Antitussive, Expectorant, and Anti-Inflammatory Bioactive Constituents in Tussilago farfara L. Based on the Spectrum-Effect Relationship Combined with Chemometrics
Yang, Liu
Jiang, Hai
Wang, Song
Hou, Ajiao
Man, Wenjing
Zhang, Jiaxu
Guo, Xinyue
Yang, Bingyou
Kuang, Haixue
Wang, Qiuhong
MOLECULES, 2020, 25 (03):
[8] Quality Evaluation and Identification of Phyllanthi fructus (Yuganzi) Based on the Spectrum-Effect Relationship
Zhou, Weiwei
Wu, Bencheng
Liu, Ling
Li, Jun
Shi, Dongdong
Li, Xiumei
SEPARATIONS, 2024, 11 (04)
[9] Research on the hemostasis and coagulation effects of Callicarpa nudiflora based on the spectrum-effect relationship
Liu, Xiaoxuan
Yang, Jianqiong
Yang, Yang
Yang, Yifang
Kang, Xingdong
Ye, Yang
Li, Xiaofeng
Wu, Yongzhong
Xiao, Junping
Li, Li
Zhang, Hongyang
Zhou, Bin
Liu, Hai
NATURAL PRODUCT RESEARCH, 2025, 39 (04) : 704 - 711
[10] Bioactive structural basis of proteoglycans from Sarcandra glabra based on spectrum-effect relationship
Sun, Xuyang
Zhao, Qianqian
Si, Yu
Li, Kaidong
Zhu, Jingyi
Gao, Xiangdong
Liu, Wei
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 259

← 1 2 3 4 5 →