P53 ALTERATION CORRELATES WITH NEGATIVE ER, NEGATIVE PGR, AND HIGH HISTOLOGIC GRADE IN BREAST-CANCER

被引：9

作者：

SASA, M ^{[1
]}

KONDO, K ^{[1
]}

KOMAKI, K ^{[1
]}

MORIMOTO, T ^{[1
]}

MONDEN, Y ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,SCH MED SCI,TOKUSHIMA 770,JAPAN

来源：

JOURNAL OF SURGICAL ONCOLOGY | 1994年 / 56卷 / 01期

关键词：

BREAST CANCER; ER; HISTOLOGIC GRADE; P53; PGR; RT-PCR-SSCP;

D O I：

10.1002/jso.2930560110

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Seventy tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the RT-PCR-SSCP method. Sixty-five samples (92.9%) were investigated in the regions of codons 101-200 and 201-300. In total, 16 samples (24.6%) showed p53 gene alteration. We found that p53 gene alteration showed a correlation with (1) a negative ER status, (2) a negative PgR status, and (3) a high histologic grade (especially numerous mitotic figures) of the tumor. However, we found no correlation between p53 gene alteration and the lymph node status or clinical stage. Thus, p53 gene alteration in breast cancer may occur in highly malignant breast cancer other than advanced clinical stage cancer or node-positive cancer. (C) 1994 Wiley-Liss, Inc.

引用

页码：46 / 50

页数：5

共 23 条

[1] HISTOLOGICAL GRADING AND PROGNOSIS IN BREAST CANCER - A STUDY OF 1409 CASES OF WHICH 359 HAVE BEEN FOLLOWED FOR 15 YEARS [J].