INDICATIONS FOR EXAMINATION OF SPONTANEOUS-ABORTION SPECIMENS - A REASSESSMENT

被引：29

作者：

WOLF, GC ^{[1
]}

HORGER, EO ^{[1
]}

机构：

[1] UNIV S CAROLINA,SCH MED,DEPT OBSTET & GYNECOL,DIV MATERNAL FETAL MED,COLUMBIA,SC 29203

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1995年 / 173卷 / 05期

关键词：

RECURRENT ABORTION; TROPHOBLAST CULTURE; KARYOTYPE;

D O I：

10.1016/0002-9378(95)90616-9

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The clinical evaluation of recurrent pregnancy loss is assessed in light of recent technical advances in trophoblast culture, ultrasonography, and chromosome analysis. With an algorithm based on karyotype results, cost-benefit calculations confirm that an average savings of $1099.47 per patient could be achieved if a policy of karyotype analysis of recurrent abortion specimens was emphasized. It is estimated that a specific chromosomal cause could be identified in 45% to 70% of such cases. A more concerted effort should be made to culture trophoblast tissue from recurrent pregnancy losses; such a policy would result in both emotional and financial rewards.

引用

页码：1364 / 1368

页数：5

共 23 条

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[22] Songster GS, Sun L, Chang SC, Sheung SW, Chromosome analysis in spontaneous pregnancy loss: use of placental villus mesodermal core cell cultures, Am J Med Genet, 42, pp. 785-788, (1992)
[23] Simpson JL, Bombard A, Chromosomal abnormalities in spontaneous abortion: frequency, pathology and genetic counselling, Spontaneous and recurrent abortion, pp. 193-213, (1987)

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