DIFFERENTIATION OF UNITED-STATES AND EUROPEAN ISOLATES OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS BY MONOCLONAL-ANTIBODIES

被引：322

作者：

NELSON, EA

CHRISTOPHERHENNINGS, J

DREW, T

WENSVOORT, G

COLLINS, JE

BENFIELD, DA

机构：

[1] CENT VET INST,DEPT VIROL,8200 AJ LELYSTAD,NETHERLANDS

[2] MAFF,CENT VET LAB,WEYBRIDGE KT15 3NB,SURREY,ENGLAND

[3] UNIV MINNESOTA,DEPT VET DIAGNOST MED,ST PAUL,MN 55108

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1993年 / 31卷 / 12期

关键词：

D O I：

10.1128/JCM.31.12.3184-3189.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Monoclonal antibodies (MAbs) to two U.S. isolates of porcine reproductive and respiratory syndrome (PRRS) virus were prepared. Two MAbs specifically recognized a conserved epitope on the putative 15-kDa nucleocapsid protein of U.S. and European isolates of PRRS virus. Four other MAbs recognized epitopes on the 15-kDa protein of U.S. but not European isolates of PRRS virus. Collectively, this indicates that PRRS viruses contain both conserved and divergent epitopes on the 15-kDa viral protein.

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页码：3184 / 3189

页数：6

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