TRANSGENE INACTIVATION - PLANTS FIGHT BACK

被引：345
作者：
FINNEGAN, J
MCELROY, D
机构：
[1] USDA ARS, ALBANY, CA 94710 USA
[2] UNIV CALIF BERKELEY, CTR PLANT GENE EXPRESS, DEPT PLANT BIOL, ALBANY, CA 94710 USA
来源：
BIO-TECHNOLOGY | 1994年 / 12卷 / 09期
关键词：
D O I：
10.1038/nbt0994-883
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Desirable new phenotypes created by the introduction of foreign DNA into plants are frequently unstable following propagation, leading to a loss of the newly acquired traits. This genetic instability is due not to deletion or mutation of the introduced DNA but rather to the inactivation of the transgene. In this review, we discuss the mechanisms that might be responsible for transgene inactivation and examine means of stabilizing gene expression in transgenic plants.
引用
收藏
页码：883 / 888
页数：6
相关论文
共 70 条
[1]   SCAFFOLD ATTACHMENT REGIONS INCREASE REPORTER GENE-EXPRESSION IN STABLY TRANSFORMED PLANT-CELLS [J].
ALLEN, GC ;
HALL, GE ;
CHILDS, LC ;
WEISSINGER, AK ;
SPIKER, S ;
THOMPSON, WF .
PLANT CELL, 1993, 5 (06) :603-613
[2]   CHANGES IN T-DNA METHYLATION AND EXPRESSION ARE ASSOCIATED WITH PHENOTYPIC VARIATION AND PLANT-REGENERATION IN A CROWN GALL TUMOR LINE [J].
AMASINO, RM ;
POWELL, ALT ;
GORDON, MP .
MOLECULAR & GENERAL GENETICS, 1984, 197 (03) :437-446
[3]   EPIGENETIC REPEAT-INDUCED GENE SILENCING (RIGS) IN ARABIDOPSIS [J].
ASSAAD, FF ;
TUCKER, KL ;
SIGNER, ER .
PLANT MOLECULAR BIOLOGY, 1993, 22 (06) :1067-1085
[4]   EXPRESSION OF A CHIMERIC NEOMYCIN PHOSPHOTRANSFERASE-II GENE IN 1ST AND 2ND GENERATION TRANSGENIC RICE PLANTS [J].
BATTRAW, M ;
HALL, TC .
PLANT SCIENCE, 1992, 86 (02) :191-202
[5]  
BOLLMANN J, 1991, PLANT CELL, V3, P1327, DOI 10.1105/tpc.3.12.1327
[6]   CHARACTERIZATION OF A PLANT SCAFFOLD ATTACHMENT REGION IN A DNA FRAGMENT THAT NORMALIZES TRANSGENE EXPRESSION IN TOBACCO [J].
BREYNE, P ;
VANMONTAGU, M ;
DEPICKER, A ;
GHEYSEN, G .
PLANT CELL, 1992, 4 (04) :463-471
[7]   PARAMUTATION [J].
BRINK, RA .
ANNUAL REVIEW OF GENETICS, 1973, 7 :129-152
[8]   SUPPRESSION OF BETA-1,3-GLUCANASE TRANSGENE EXPRESSION IN HOMOZYGOUS PLANTS [J].
DECARVALHO, F ;
GHEYSEN, G ;
KUSHNIR, S ;
VANMONTAGU, M ;
INZE, D ;
CASTRESANA, C .
EMBO JOURNAL, 1992, 11 (07) :2595-2602
[9]   IDENTIFICATION OF PLANT GENETIC-LOCI INVOLVED IN A POSTTRANSCRIPTIONAL MECHANISM FOR MEIOTICALLY REVERSIBLE TRANSGENE SILENCING [J].
DEHIO, C ;
SCHELL, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (12) :5538-5542
[10]   EXPRESSION AND INHERITANCE OF KANAMYCIN RESISTANCE IN A LARGE NUMBER OF TRANSGENIC PETUNIAS GENERATED BY AGROBACTERIUM-MEDIATED TRANSFORMATION [J].
DEROLES, SC ;
GARDNER, RC .
PLANT MOLECULAR BIOLOGY, 1988, 11 (03) :355-364
1234567