PROTEIN-SYNTHESIS IN DIFFERENT CELL-LINES INFECTED WITH ORTHOREOVIRUS SEROTYPE-3 - INHIBITION OF HOST-CELL PROTEIN-SYNTHESIS CORRELATES WITH ACCELERATED VIRAL MULTIPLICATION AND CELL-KILLING

被引：20

作者：

DANIS, C ^{[1
]}

LEMAY, G ^{[1
]}

机构：

[1] UNIV MONTREAL,DEPT MICROBIOL & IMMUNOL,BP 6128,STN A,MONTREAL H3C 3J7,QUEBEC,CANADA

来源：

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 1993年 / 71卷 / 1-2期

关键词：

REOVIRUS; PROTEIN SYNTHESIS INHIBITION; VIRAL MULTIPLICATION; CYTOPATHIC EFFECTS;

D O I：

10.1139/o93-012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we examined the viral multiplication of human reovirus serotype 3 in mammalian cell lines of different species and tissue origins. All cell lines supported viral multiplication to a similar extent, although the kinetics was significantly different in some of these lines. The appearance of infectious virus was delayed in few cell lines. These cell lines also exhibited a much slower rate of cell killing, and in contrast to the others, did not exhibit an inhibition of the synthesis of host-cell proteins. We conclude that the inhibition correlates with rapid cell killing and viral multiplication, while being unrelated to efficient total viral production.

引用

页码：81 / 85

页数：5