PROTEIN-SYNTHESIS IN DIFFERENT CELL-LINES INFECTED WITH ORTHOREOVIRUS SEROTYPE-3 - INHIBITION OF HOST-CELL PROTEIN-SYNTHESIS CORRELATES WITH ACCELERATED VIRAL MULTIPLICATION AND CELL-KILLING

In this study, we examined the viral multiplication of human reovirus serotype 3 in mammalian cell lines of different species and tissue origins. All cell lines supported viral multiplication to a similar extent, although the kinetics was significantly different in some of these lines. The appearance of infectious virus was delayed in few cell lines. These cell lines also exhibited a much slower rate of cell killing, and in contrast to the others, did not exhibit an inhibition of the synthesis of host-cell proteins. We conclude that the inhibition correlates with rapid cell killing and viral multiplication, while being unrelated to efficient total viral production.