LOCALIZATION OF ANGIOTENSIN AT1 RECEPTORS IN THE RAT-HEART CONDUCTION SYSTEM

被引：28
|
作者：
SAAVEDRA, JM
VISWANATHAN, M
SHIGEMATSU, K
机构：
[1] Section on Pharmacology, Laboratory of Clinical Science, NIMH, Building 10, Room 2D-45, 9000 Rockville Pike, Bethesda
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 235卷 / 2-3期
关键词：
SINOATRIAL NODE; ATRIOVENTRICULAR NODE; ANGIOTENSIN SYSTEM; ANGIOTENSIN RECEPTORS; LOSARTAN;
D O I：
10.1016/0014-2999(93)90150-G
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We characterized angiotensin II receptor subtypes in the conduction system of the rat heart using quantitative autoradiography. In both the sinoatrial and atrioventricular nodes, binding could be totally displaced by losartan, and was insensitive to PD 123177, indicating that angiotensin II receptors in the conduction system of the rat heart belong to the AT1 subtype. Angiotensin AT1 receptors could play a direct role in the regulation of the heart chronotropic properties.
引用
收藏
页码：301 / 303
页数：3
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