SIGNAL TRANSDUCTION AND THE ACTIN CYTOSKELETON - THE ROLES OF MARCKS AND PROFILIN

被引：207
|
作者：
ADEREM, A
机构：
[1] Laboratory of Signal Transduction, The Rockefeller University, New York, NY 10021
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 10期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0968-0004(92)90016-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MARCKS and profilin, two actin-binding proteins, are discussed to illustrate the mechanism by which extracellular signals are coupled to changes in the structure of the actin cytoskeleton. MARCKS is a filamentous actin-crosslinking protein that appears to function as an integrator of protein kinase C and calcium (Ca2+)/calmodulin signals in the regulation of actin-membrane interactions. New data suggest that profilin is activated by the coordinated action of receptor tyrosine kinases and phospholipase C-gamma1 to stimulate the stabilization of actin filaments.
引用
收藏
页码：438 / 443
页数：6
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