SIGNAL TRANSDUCTION AND THE ACTIN CYTOSKELETON - THE ROLES OF MARCKS AND PROFILIN

被引：207
|
作者：
ADEREM, A
机构：
[1] Laboratory of Signal Transduction, The Rockefeller University, New York, NY 10021
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 10期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0968-0004(92)90016-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MARCKS and profilin, two actin-binding proteins, are discussed to illustrate the mechanism by which extracellular signals are coupled to changes in the structure of the actin cytoskeleton. MARCKS is a filamentous actin-crosslinking protein that appears to function as an integrator of protein kinase C and calcium (Ca2+)/calmodulin signals in the regulation of actin-membrane interactions. New data suggest that profilin is activated by the coordinated action of receptor tyrosine kinases and phospholipase C-gamma1 to stimulate the stabilization of actin filaments.
引用
收藏
页码：438 / 443
页数：6
相关论文
共 50 条
  • [31] Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena
    Kiss, Viktoria
    Jipa, Andras
    Varga, Kata
    Takats, Szabolcs
    Maruzs, Tamas
    Lorincz, Peter
    Simon-Vecsei, Zsofia
    Szikora, Szilard
    Foldi, Istvan
    Bajusz, Csaba
    Toth, David
    Vilmos, Peter
    Gaspar, Imre
    Ronchi, Paolo
    Mihaly, Jozsef
    Juhasz, Gabor
    CELL DEATH AND DIFFERENTIATION, 2020, 27 (05): : 1677 - 1692
  • [32] Transduction of cyclic axial substrate strain through actin cytoskeleton
    Wang, HC
    Grood, ES
    FASEB JOURNAL, 1996, 10 (03): : 139 - 139
  • [33] ROLES OF CALDESMON IN CELL MOTILITY AND ACTIN CYTOSKELETON REMODELING
    Lin, Jim Jung-Ching
    Li, Yan
    Eppinga, Robbin D.
    Wang, Qinchuan
    Jin, Jian-Ping
    INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 274, 2009, 274 : 1 - 68
  • [34] Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena
    Viktória Kiss
    András Jipa
    Kata Varga
    Szabolcs Takáts
    Tamás Maruzs
    Péter Lőrincz
    Zsófia Simon-Vecsei
    Szilárd Szikora
    István Földi
    Csaba Bajusz
    Dávid Tóth
    Péter Vilmos
    Imre Gáspár
    Paolo Ronchi
    József Mihály
    Gábor Juhász
    Cell Death & Differentiation, 2020, 27 : 1677 - 1692
  • [35] Multiple roles for the actin cytoskeleton during regulated exocytosis
    Natalie Porat-Shliom
    Oleg Milberg
    Andrius Masedunskas
    Roberto Weigert
    Cellular and Molecular Life Sciences, 2013, 70 : 2099 - 2121
  • [36] Emerging roles of the actin cytoskeleton in cholangiocyte function and disease
    Doctor, RB
    Fouassier, L
    SEMINARS IN LIVER DISEASE, 2002, 22 (03) : 263 - 276
  • [37] Multiple roles for the actin cytoskeleton during regulated exocytosis
    Porat-Shliom, Natalie
    Milberg, Oleg
    Masedunskas, Andrius
    Weigert, Roberto
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (12) : 2099 - 2121
  • [38] Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin'?
    Rothenfluh, Adrian
    Cowan, Christopher W.
    CURRENT OPINION IN NEUROBIOLOGY, 2013, 23 (04) : 507 - 512
  • [39] SIGNAL TRANSDUCTION, CYTOSKELETON, AND SMALL GTPASES - THE GAP CONNECTION
    FORT, P
    VINCENT, S
    M S-MEDECINE SCIENCES, 1993, 9 (01): : 59 - 65
  • [40] Unconventional myosins at the crossroad of signal transduction and cytoskeleton remodeling
    Soldati, T
    Schwarz, EC
    Geissler, H
    PROTOPLASMA, 1999, 209 (1-2) : 28 - 37
12345