INHIBITION OF ACETYL-COENZYME A CARBOXYLASE BY THE NOVEL GRASS-SELECTIVE HERBICIDE 3-(2,4-DICHLOROPHENYL)-PERHYDROINDOLIZINE-2,4-DIONE

被引：17

作者：

BABCZINSKI, P ^{[1
]}

FISCHER, R ^{[1
]}

机构：

[1] BAYER AG,PFLANZENSCHUTZZENTRUM MONHEIM,CHEM RES,W-5090 LEVERKUSEN,GERMANY

来源：

PESTICIDE SCIENCE | 1991年 / 33卷 / 04期

关键词：

D O I：

10.1002/ps.2780330408

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

The novel herbicidal compound 3-(2,4-dichlorophenyl)-perhydroindolizine-2,4-dione which is active as a pre- and post-emergence grass-selective herbicide is a new type of inhibitor of plant acetyl-coenzyme A carboxylase (ACCase; E. C. 6.4.1.2). This has been demonstrated by in-vitro experiments using isolated corn enzyme. Besides an I50 value of 4.7-mu-M under the assay conditions used, a mixed-type inhibitory activity on the enzyme is established. The compound is inactive on rat liver ACCase enzyme and shows decreased activity (pI50 less than 3.0) on the spinach enzyme.

引用

页码：455 / 466

页数：12

共 18 条

[1] INHIBITORS OF PYRUVATE-DEHYDROGENASE AS HERBICIDES [J].

BAILLIE, AC ;

WRIGHT, K ;

WRIGHT, BJ ;

EARNSHAW, CG .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1988, 30 (02) :103-112

[2] INHIBITION OF PLANT ACETYL-COENZYME A CARBOXYLASE BY THE HERBICIDES SETHOXYDIM AND HALOXYFOP [J].

BURTON, JD ;

GRONWALD, JW ;

SOMERS, DA ;

CONNELLY, JA ;

GENGENBACH, BG ;

WYSE, DL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (03) :1039-1044

[3] ALLICIN, A NATURALLY-OCCURRING ANTIBIOTIC FROM GARLIC, SPECIFICALLY INHIBITS ACETYL-COA SYNTHETASE [J].

FOCKE, M ;

FELD, A ;

LICHTENTHALER, HK .

FEBS LETTERS, 1990, 261 (01) :106-108

[4] INFLUENCE OF S-ETHYL DIPROPYLTHIOCARBAMATE (EPTC) ON WHEAT ROOT PHOSPHOLIPID FATTY-ACID COMPOSITION [J].

KARUNEN, P ;

WILKINSON, RE .

PHYSIOLOGIA PLANTARUM, 1975, 35 (03) :228-231

[5]

KOBEK K, 1988, Z NATURFORSCH C, V43, P47

[6] METABOLISM OF 1-AMINOETHYLPHOSPHINATE GENERATES ACETYLPHOSPHINATE, A POTENT INHIBITOR OF PYRUVATE-DEHYDROGENASE [J].

LABER, B ;

AMRHEIN, N .

BIOCHEMICAL JOURNAL, 1987, 248 (02) :351-358

[7]

MURTHY AR, 1985, J MED CHEM, V28, P1591, DOI 10.1021/jm00149a008

[8] ANTIBIOTIC CERULENIN, A NOVEL TOOL FOR BIOCHEMISTRY AS AN INHIBITOR OF FATTY-ACID SYNTHESIS [J].

OMURA, S .

BACTERIOLOGICAL REVIEWS, 1976, 40 (03) :681-697

[9]

Rendina A. R., 1989, Proceedings of the Brighton Crop Protection Conference, Weeds., P163

[10] KINETIC CHARACTERIZATION, STEREOSELECTIVITY, AND SPECIES SELECTIVITY OF THE INHIBITION OF PLANT ACETYL-COA CARBOXYLASE BY THE ARYLOXYPHENOXYPROPIONIC ACID GRASS HERBICIDES [J].

RENDINA, AR ;

FELTS, JM ;

BEAUDOIN, JD ;

CRAIGKENNARD, AC ;

LOOK, LL ;

PARASKOS, SL ;

HAGENAH, JA .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 265 (01) :219-225

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