BIFUNCTIONAL EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA ON MIGRATION OF CULTURED RAT AORTIC SMOOTH-MUSCLE CELLS

被引：67
作者：
KOYAMA, N
KOSHIKAWA, T
MORISAKI, N
SAITO, Y
YOSHIDA, S
机构：
[1] The Second Department of Internal Medicine, School of Medicine, Chiba University, Chiba
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)90391-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Migration of smooth muscle cells (SMC) in the arterial wall is important in the pathogenesis of atherosclerosis and is presumably regulated in both normal and atherosclerotic tissues. In this study, the effect of transforming growth factor-β (TGF-β) on the migration of rat aortic SMC was examined. TGF-β alone enhanced the migration of SMC at concentrations of 10 to 50 pg/ml and its maximal effect was similar to that of platelet-derived growth factor (PDGF). Checker board analysis showed that TGF-β had a chemotactic, but not a chemokinetic effect. PDGF also enhanced the migration in a dose-dependent manner and TGF-β inhibited the PDGF-induced the migration dose-dependently at 1.0 pg/ml to 1.0 ng/ml. These data suggest that TGF-β is a bifunctional regulator of the migration of aortic SMC. © 1990.
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页码：725 / 729
页数：5
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