OKADAIC ACID - A NEW PROBE FOR THE STUDY OF CELLULAR-REGULATION

被引:1447
作者
COHEN, P
HOLMES, CFB
TSUKITANI, Y
机构
[1] FUJISAWA CHEM CO,TOKYO,JAPAN
[2] NATL RES COUNCIL CANADA,MONTREAL,QUEBEC,CANADA
基金
英国医学研究理事会;
关键词
D O I
10.1016/0968-0004(90)90192-E
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The tumour promoter okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A. Here we review recent studies which demonstrate that this toxin is extremely useful for identifying biological processes that are controlled through the reversible phosphorylation of proteins. © 1990.
引用
收藏
页码:98 / 102
页数:5
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