HIGH-MOLECULAR-WEIGHT AGGREGATE CONTENT OF HEATED AND UNHEATED FACTOR-VIII PRODUCTS DETERMINED BY FAST-PROTEIN LIQUID-CHROMATOGRAPHY

被引：4
|
作者：
DAWES, J
FREEMAN, L
DAWSON, NJ
PEPPER, DS
BARROWCLIFFE, TW
机构：
[1] MRC,SCOTTISH NATL BLOOD TRANSFUS SERV,BLOOD COMPONENTS ASSAY GRP,EDINBURGH,SCOTLAND
[2] SCOTTISH NATL BLOOD TRANSFUS SERV,HEADQUARTERS LAB,EDINBURGH,SCOTLAND
[3] NATL INST BIOL STAND & CONTROLS,POTTERS BAR,ENGLAND
来源：
VOX SANGUINIS | 1990年 / 58卷 / 01期
关键词：
D O I：
10.1111/j.1423-0410.1990.tb02051.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Abstract. The molecular‐weight distribution of proteins in factor VIII concentrates has been analysed by fast‐protein liquid chromatography. The proportion of high‐molecular‐weight (HMW) aggregates in one product increased on freeze‐drying and heating, with fibrinogen and fibronectin being the main protein components of the HMW peak. In all other concentrates, the HMW peak was less than or equal to 5% of the total protein content and there were no differences in HMW content according to purity or method of viral inactivation. © 1990 S. Karger AG, Basel
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页码：30 / 34
页数：5
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