COMPETITIVE-INHIBITION BETWEEN FOLIC-ACID AND METHOTREXATE FOR TRANSPORT CARRIER IN THE RAT SMALL-INTESTINE

被引：15

作者：

CHUNGI, VS ^{[1
]}

BOURNE, DWA ^{[1
]}

DITTERT, LW ^{[1
]}

机构：

[1] UNIV KENTUCKY,COLL PHARM,LEXINGTON,KY 40506

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 12期

关键词：

Antineoplastic agents—methotrexate; absorption; rat small intestine; competitive inhibition by folic acid; Folic acid—absorption; competitive inhibition by methotrexate; Intestinal absorption—folic acid; methotrexate; competitive inhibition; rats; Methotrexate—absorption;

D O I：

10.1002/jps.2600681225

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Folic acid absorption from the lumen of the rat small intestine in situ obeyed Michaelis‐Menten kinetics. The values of Vmax and Km for absorption were 4.63 × 10−7 M/min and 1.21 × 10−6 M, respectively. Folic acid and methotrexate were mutual competitive inhibitors of absorption. Their Ki values were 1.28 × 10−6 and 1.9 × 10−5 M, respectively. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1552 / 1553

页数：2

共 14 条

[1]

CHELLO PL, 1977, CANCER RES, V37, P4297

[2] DRUG ABSORPTION .8. KINETICS OF GI ABSORPTION OF METHOTREXATE [J].