METABOLISM OF [C-14]-DEBRISOQUINE IN MAN

被引：76

作者：

IDLE, JR

MAHGOUB, A

ANGELO, MM

DRING, LG

LANCASTER, R

SMITH, RL

机构：

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 7卷 / 03期

关键词：

D O I：

10.1111/j.1365-2125.1979.tb00930.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The synthesis of [14C]‐debrisoquine hydrochloride and 4‐hydroxy‐ debrisoquine sulphate is described. 2 The metabolic fate and excretion profile in both urine and faeces of 14C‐labelled debrisoquine was studied in five healthy human subjects. 3 Investigations showed that the drug is well‐absorbed after a single oral dose of 32 mg and quantitatively eliminated from the body within three days. 4 4‐Hydroxy‐ debrisoquine is the major metabolite of debrisoquine, although significant amounts of 5‐,6‐, 7‐ and 8‐hydroxy‐debrisoquine are also formed. 5 Electron‐capture gas chromatography is a useful method for measuring debrisoquine and its five hydroxylated metabolites in urine at the pg level. 1979 The British Pharmacological Society

引用

页码：257 / 266

页数：10

共 30 条

[1] METABOLISM OF DEBRISOQUINE SULFATE IN RAT, DOG AND MAN [J].