DNA DOUBLE-STRAND BREAK REPAIR AND V(D)J RECOMBINATION - INVOLVEMENT OF DNA-PK

被引：330
作者：
JACKSON, SP
JEGGO, PA
机构：
[1] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE,ENGLAND
[2] UNIV SUSSEX,MRC,CELL MUTAT UNIT,BRIGHTON BN1 9RR,E SUSSEX,ENGLAND
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 10期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0968-0004(00)89090-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.
引用
收藏
页码：412 / 415
页数：4
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