ULTRAVIOLET-B IRRADIATION INCREASES ENDOTHELIN-1 AND ENDOTHELIN RECEPTOR EXPRESSION IN CULTURED HUMAN KERATINOCYTES

被引：35
作者：
TSUBOI, R [1 ]
SATO, C [1 ]
OSHITA, Y [1 ]
HAMA, H [1 ]
SAKURAI, T [1 ]
GOTO, K [1 ]
OGAWA, H [1 ]
机构：
[1] UNIV TSUKUBA,INST BASIC MED SCI,DEPT PHARMACOL,TSUKUBA,IBARAKI 305,JAPAN
来源：
FEBS LETTERS | 1995年 / 371卷 / 02期
关键词：
ENDOTHELIN-1; ENDOTHELIN RECEPTOR; ULTRAVIOLET B; KERATINOCYTE;
D O I：
10.1016/0014-5793(95)00912-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of ultraviolet B (UVB) irradiation on endothelin-l (ET-1) and ET receptor expression was examined using cultured normal human keratinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.1 pg/day/10(5) cells. UVB irradiation up to 10 mJ/cm(2) increased ET-I secretion 3-fold, and potentiated expression of mRNA for ET-1. Both ET(A) and ET(B) receptor mRNAs were detected in keratinocytes, and their expression was up-regulated by 5 mJ/cm(2) UVB irradiation.
引用
收藏
页码：188 / 190
页数：3
相关论文
共 32 条
  • [1] ARAI H, 1990, NATURE, V248, P730
  • [2] GROWTH REGULATORY PROPERTIES OF ENDOTHELINS
    BATTISTINI, B
    CHAILLER, P
    DORLEANSJUSTE, P
    BRIERE, N
    SIROIS, P
    [J]. PEPTIDES, 1993, 14 (02) : 385 - 399
  • [3] CALCIUM-REGULATED DIFFERENTIATION OF NORMAL HUMAN EPIDERMAL-KERATINOCYTES IN CHEMICALLY DEFINED CLONAL CULTURE AND SERUM-FREE SERIAL CULTURE
    BOYCE, ST
    HAM, RG
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1983, 81 (01) : S33 - S40
  • [4] ENDOTHELIN STIMULATES DNA-SYNTHESIS IN SWISS 3T3 CELLS - SYNERGY WITH POLYPEPTIDE GROWTH-FACTORS
    BROWN, KD
    LITTLEWOOD, CJ
    [J]. BIOCHEMICAL JOURNAL, 1989, 263 (03) : 977 - 980
  • [5] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
  • [6] ENDOTHELIN - A NEW CHALLENGE
    DOHERTY, AM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (09) : 1493 - 1508
  • [7] REGULATION OF ENDOTHELIN-1 SYNTHESIS IN CULTURED GUINEA-PIG AIRWAY EPITHELIAL-CELLS BY VARIOUS CYTOKINES
    ENDO, T
    UCHIDA, Y
    MATSUMOTO, H
    SUZUKI, N
    NOMURA, A
    HIRATA, F
    HASEGAWA, S
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 186 (03) : 1594 - 1599
  • [8] CLONING AND EXPRESSION OF HUMAN ENDOTHELIN-1 RECEPTOR CDNA
    HOSODA, K
    NAKAO, K
    HIROSHIARAI
    SUGA, S
    OGAWA, Y
    MUKOYAMA, M
    SHIRAKAMI, G
    SAITO, Y
    NAKANISHI, S
    IMURA, H
    [J]. FEBS LETTERS, 1991, 287 (1-2) : 23 - 26
  • [9] IMOKAWA G, 1992, J BIOL CHEM, V267, P24675
  • [10] THE HUMAN ENDOTHELIN FAMILY - 3 STRUCTURALLY AND PHARMACOLOGICALLY DISTINCT ISOPEPTIDES PREDICTED BY 3 SEPARATE GENES
    INOUE, A
    YANAGISAWA, M
    KIMURA, S
    KASUYA, Y
    MIYAUCHI, T
    GOTO, K
    MASAKI, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) : 2863 - 2867
1234