CHOLESTEROL-CONTAINING NONIONIC AMPHIPHILIC POLYMERS - SYNTHESIS AND SOLUBILIZATION OF CHOLESTEROL

被引：5
|
作者：
CHO, I [1 ]
JEONG, SW [1 ]
机构：
[1] KOREA ADV INST SCI & TECHNOL, DEPT CHEM, TAEJON 305701, SOUTH KOREA
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 1995年 / 196卷 / 03期
关键词：
D O I：
10.1002/macp.1995.021960315
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Solubilization of cholesterol in water with cholesterol-containing poly(N-vinyl-2-pyrrolidone) was studied. The non-ionic amphiphilic polymers were synthesized via copolymerization of cholesterol-based monomers with N-vinyl-2-pyrrolidone; the copolymers were dissolved isotropically in water to form hydrophobic microdomains solubilizing cholesterol efficiently. Electron micrographs revealed that the amphiphilic polymers undergo aggregational changes from random microphases to bilayers as free cholesterol is incorporated into the polymeric hydrophobic domains.
引用
收藏
页码：869 / 875
页数：7
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