ENHANCEMENT OF THE ANTINEOPLASTIC EFFECT OF ANTICARCINOGENS ON BENZO[A]PYRENE-TREATED WISTAR RATS, IN RELATION TO THEIR NUMBER AND BIOLOGICAL-ACTIVITY

被引：10
作者：
KALLISTRATOS, G
EVANGELOU, A
AGNANTIS, N
FASSKE, E
KARKABOUNAS, S
DONOS, A
机构：
[1] UNIV IOANNINA,FAC MED,DEPT PATHOL,GR-45110 IOANNINA,GREECE
[2] RES INST EXPTL BIOL & MED,DEPT PATHOL,D-23845 BORSTEL,GERMANY
来源：
CANCER LETTERS | 1994年 / 82卷 / 02期
关键词：
ANTINEOPLASTIC EFFECT; BENZO[A]PYRENE; WISTAR RATS;
D O I：
10.1016/0304-3835(94)90006-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Naturally occurring anticarcinogens, such as vitamins C and E, and the microelement selenium were found to inhibit the induction of benzo[a]pyrene-induced malignant tumors in Wistar rats to various extends. The antineoplastic effect of the tested anticarcinogens is gradually increased according to the number of inhibitors selected. To date the maximum action against malignancy is manifested by use of the above three inhibitors. In the group of rats receiving vitamins C, E and selenium, the prolongation of life induced by adding more than one anticarcinogen to the treatment regime reached, and in some cases surpassed, the normal life expectancy of the rats. It is expected that by adding even more anticarcinogens, the antineoplastic potency (Ap) of the inhibitors will be further improved. These results encouraged us to conduct a clinical trial in terminal human cancer cases, in conjuction with the usual treatments of surgery or chemotherapy and irradiation.
引用
收藏
页码：153 / 165
页数：13
相关论文
共 43 条
[11]  
CRABTREE HG, 1945, CANCER RES, V5, P346
[12]   PLATELET-ACTIVATING-FACTOR (PAF) - IMPLICATIONS FOR CORONARY HEART AND VASCULAR DISEASES [J].
EVANGELOU, AM .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1994, 50 (01) :1-28
[13]  
Griffin A C, 1979, Adv Cancer Res, V29, P419, DOI 10.1016/S0065-230X(08)60851-9
[14]  
HARBER SL, 1962, P SOC EXP BIOL MED, V111, P774
[15]  
HARMAN D, 1969, Clinical Medicine, V17, P125
[16]  
JAAKKOLA K, 1992, ANTICANCER RES, V12, P599
[17]  
Jaffe W. G., 1946, EXPTL MED AND SURG, V4, P278
[18]  
KALLISTRATOS G, 1972, ARZNEI-FORSCHUNG, V22, P1434
[19]   EFFECT OF 3,4-BENZPYRENE IN LARGE MAMMALS [J].
KALLISTRATOS, G .
NATURWISSENSCHAFTEN, 1971, 58 (04) :222-+
[20]   SIGNIFICANCE OF CIS-ACONITIC ACID FOR BIOLOGICAL INACTIVATION OF 3,4-BENZOPYRENE CANCEROGENESIS [J].
KALLISTRATOS, G .
EXPERIENTIA, 1975, 31 (04) :490-491
12345