PROTECTIVE EFFECT OF GLUTATHIONE AND SELENIUM AGAINST ALLOXAN-INDUCED LIPID-PEROXIDATION AND LOSS OF ANTIOXIDANT ENZYMES IN ERYTHROCYTES

被引：3

作者：

YADAV, P ^{[1
]}

SARKAR, S ^{[1
]}

BHATNAGAR, D ^{[1
]}

机构：

[1] DA UNIV,SCH BIOCHEM,INDORE 452001,INDIA

来源：

JOURNAL OF BIOSCIENCES | 1994年 / 19卷 / 01期

关键词：

LIPID PEROXIDATION; SUPEROXIDE DISMUTASE; CATALASE; GLUTATHIONE PEROXIDASE; ALLOXAN;

D O I：

10.1007/BF02703464

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alloxan is a diabetogenic drug and is known to induce diabetes through generation of free radicals. The toxic oxygen species can be detoxified by antioxidant enzyme system and thus reduce the deleterious effect of lipid peroxidation. Erythrocytes exposed to alloxan induced lipid peroxidation in vivo as well as in vitro. Although alloxan treatment produced a deleterious effect on antioxidant enzymes, pretreatment with glutathione and selenium led to a recovery of the activities of superoxide dismutase and glutathione peroxidase. However, catalase activity increased on alloxan treatment. Alloxan reduced blood glucose level significantly within 60 min but thereafter a slow and steady rise was observed.

引用

页码：19 / 25

页数：7

共 22 条

[1]

Aebi H., 1983, METHODS ENZYMATIC AN, P276, DOI DOI 10.1016/J.REPROTOX.2005.05.003

[2] CURRENT CONCEPTS CONCERNING RADIOPROTECTIVE AND CRYOPROTECTIVE PROPERTIES OF DIMETHYL-SULFOXIDE IN CELLULAR SYSTEMS [J].