A DISTAL REGION OF THE CALC-1 GENE IS NECESSARY FOR REGULATED ALTERNATIVE SPLICING

被引：4

作者：

HORN, DA ^{[1
]}

LATCHMAN, DS ^{[1
]}

机构：

[1] UCL, SCH MED,DIV MOLEC PATHOL,WINDEYER BLDG, CLEVELAND ST, LONDON W1P 6DB, ENGLAND

来源：

FEBS LETTERS | 1993年 / 324卷 / 02期

关键词：

ALTERNATIVE SPLICING; CALCITONIN; CALCITONIN GENE RELATED PEPTIDE; GENE REGULATION;

D O I：

10.1016/0014-5793(93)81376-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CALC-1 gene exhibits tissue specific alternative splicing with exons 1-4 being spliced to produce the calcitonin mRNA in thyroid C cells and exons 1-3 and 5-6 being joined to produce the CGRP mRNA in neuronal cells. Previous studies have identified an element in intron 3 within the alternatively spliced region which is critical for this effect to occur. We show here that deletion of sequences downstream of the alternatively spliced region also disrupts the tissue specific pattern of alternative splicing. The manner in which these sequences act is discussed.

引用

页码：123 / 126

页数：4

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