CYTOGENETIC EFFECT OF MALATHION IN INVITRO CULTURE OF HUMAN PERIPHERAL-BLOOD

被引：28

作者：

BALAJI, M ^{[1
]}

SASIKALA, K ^{[1
]}

机构：

[1] BHARATHIAR UNIV,DEPT ZOOL,DIV HUMAN GENET,COIMBATORE 641046,INDIA

来源：

MUTATION RESEARCH | 1993年 / 301卷 / 01期

关键词：

SISTER-CHROMATID EXCHANGE; MITOTIC INDEX; CHROMOSOMAL ABERRATIONS;

D O I：

10.1016/0165-7992(93)90050-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosomal aberrations, sister-chromatid exchanges and mitotic indices were observed in human peripheral leukocytes, treated with four different concentrations of malathion (0.02, 0.2, 2 and 20 mug/ml), an organophosphate pesticide, added to the culture medium at 0, 24 and 48 h after culture initiation. These cultures showed a dose-dependent increase in the frequency of chromosomal aberration as well as sister-chromatid exchanges. There was a significant decrease in mitotic index at all concentrations.

引用

页码：13 / 17

页数：5

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