ROLE OF THE DOPAMINERGIC SYSTEM IN DEPRESSION

被引：307
作者：
KAPUR, S [1 ]
MANN, JJ [1 ]
机构：
[1] UNIV PITTSBURGH, WESTERN PSYCHIAT INST & CLIN,SCH MED, DEPT PSYCHIAT,NEUROPHARMACOL LABS, PITTSBURGH, PA 15213 USA
来源：
BIOLOGICAL PSYCHIATRY | 1992年 / 32卷 / 01期
关键词：
D O I：
10.1016/0006-3223(92)90137-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A hypothesis implicating dopamine in depression was proposed over 15 years ago (Randrup et al 1975). The identification of multiple new subtypes of dopamine receptors and evolving views regarding the function of the dopamine systems in the brain require a reexamination of this hypothesis. Results from studies in depression, Parkinson's disease, and animal models of depression suggest a deficiency of dopamine in depression. Dopamine precursors, dopamine agonists, and dopamine reputake inhibitors show therapeutic efficacy in depression. Electroconvulsive therapy (ECT) and standard pharmacological antidepressants enhance dopamine function. Studies using receptor-specific drugs in clinical trials and neuroimaging studies are needed to further clarify the role of dopamine in depression.
引用
收藏
页码：1 / 17
页数：17
相关论文
共 127 条
[21]   EFFECT OF LONG-TERM AMINEPTINE TREATMENT ON PRESYNAPTIC AND POSTSYNAPTIC MECHANISMS IN RAT-BRAIN [J].
CECI, A ;
GARATTINI, S ;
GOBBI, M ;
MENNINI, T .
BRITISH JOURNAL OF PHARMACOLOGY, 1986, 88 (01) :269-275
[22]   ELECTROCONVULSIVE SHOCK - PROGRESSIVE DOPAMINE AUTORECEPTOR SUBSENSITIVITY INDEPENDENT OF REPEATED TREATMENT [J].
CHIODO, LA ;
ANTELMAN, SM .
SCIENCE, 1980, 210 (4471) :799-801
[23]   EFFECT OF ECT ON THE NEUROENDOCRINE RESPONSE TO APOMORPHINE IN SEVERELY DEPRESSED-PATIENTS [J].
CHRISTIE, JE ;
WHALLEY, LJ ;
BROWN, NS ;
DICK, H .
BRITISH JOURNAL OF PSYCHIATRY, 1982, 140 (MAR) :268-273
[24]  
COSTAIN DW, 1982, LANCET, V2, P400
[25]   FURTHER ASPECTS OF NOMIFENSINE PHARMACOLOGY [J].
COSTALL, B ;
NAYLOR, RJ .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1977, 4 :S89-S99
[26]   BEHAVIORAL EVIDENCE OF DOPAMINE RECEPTOR STIMULATION BY PIRIBEDIL (ET495) AND ITS METABOLITE S584 [J].
CREESE, I .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1974, 28 (01) :55-58
[27]  
CREESE I, 1985, ANN REV PSYCHIATRY, V4, P17
[28]  
Cummings J L, 1985, Adv Psychosom Med, V13, P111
[29]   STUDIES ON POSSIBLE MECHANISMS OF ACTION OF ELECTROCONVULSIVE-THERAPY - EFFECTS OF REPEATED ELECTRICALLY INDUCED SEIZURES ON RAT-BRAIN RECEPTORS FOR MONOAMINES AND OTHER NEUROTRANSMITTERS [J].
DEAKIN, JFW ;
OWEN, F ;
CROSS, AJ ;
DASHWOOD, MJ .
PSYCHOPHARMACOLOGY, 1981, 73 (04) :345-349
[30]  
DELZOMPO M, 1990, ADV BIOSCI, V77, P177
12345678910