GENERAL PATHOGENESIS OF DIFFUSE ALVEOLAR-INTERSTITIAL LUNG-DISEASE

Diffuse alveolar-interstitial lugd disease is a syndrome characterized, amongst others, by a common pathogenic scheme. The different phases of its pathogenesis are reviewed in this work. First of all, the concept of alveolitis is described, indicating its characteristics and general consequences of this lesion. Secondly, the different agents wich could leed to the destruction of alveolar and interstitial structures, specially those of macrophagic origen, are reviewed. Next, the different types of granulomas, cells of wich they are formed, and their general production mechanism are described. Finally the concept of lung fibrosis are reviewed, studying the different processes which lead to increased collagen in the interstitial tissue, specially chemotaxis and fibroblastic proliferative factors.